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Orphan receptor data sheet

This GPR61 orphan receptor data sheet provides a clear and well-organized summary of its structure, function, role in the body, and potential medical importance. The information is based on thorough research, ensuring accuracy and relevance. The paper follows APA formatting, with references cited in Vancouver style, and is written in a simple, easy-to-understand way for college students and researchers. This one-page A4 document serves as a useful and reliable resource for anyone studying orphan receptors in medical science.

February 1, 2025

* The sample essays are for browsing purposes only and are not to be submitted as original work to avoid issues with plagiarism.

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GPR61 Orphan Receptor Data Sheet
Orphan Receptor Name: GPR61
Description: GPCR (class A) (1)
Other names: Probable GPCR61 (2)
Molecular information: Human 451aa; chr. 1p13.3; Accession No. Q9BZJ8
Rat 451aa; chr. 2Q34: Accession No. Q8K4S5
Mouse 451aa; chr.3: Accession No. Q8R4N2 (3, 4, 5)
Structural information: (human) 7TMDs (1,4)
Homology with other receptors: 28-31% with certain histamine, adrenergic, serotonin,
and dopamine receptors (6)
Tissue location: Brain, particularly in hypothalamus and pituitary gland (5)
Putative ligand(s): No endogenous ligands (Orphan receptor) (5)
Agonists: none known
Antagonists: none known
Radioligands: none known
Principal transduction pathway: Gs-alpha/cAMP (6)
Physiological importance: Role in the regulation of appetite and body weight (1)
Pharmacological importance: Possible target for therapeutic interventions in metabolic
disorders such as obesity (1)
Mutations and Pathophysiology: None known (No specific mutations linked to human
diseases)
Comments: Inverse agonists for GPR61 have been identified and they act though a G-
protein dependent signaling pathway, thus providing concepts into their functional
modulation.
Abbreviations: GPCR- G-protein coupled receptor, aa - amino acid, chr – chromosome
References List
1. Lees JA, Dias JM, Rajamohan F, et al. An inverse agonist of orphan receptor GPR61
acts by a G protein-competitive allosteric mechanism. NC. 2023; 14(1): 5938. Doi:
10.1038/s41467-023-41646-3.
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2. Dai P, Chen C, Yu J, Ma C, Zhang X. New insights into sperm physiology regulation:
Enlightenment from G-protein-coupled receptors. Andr. 2024; 12(6): 1253-1271.
https://doi.org/10.1111/andr.13593
3. Alexander S, Arthur C, Kelly E, Davenport, A, Mathie A, Peters J, et al. The concise
guide to pharmacology 2021/22: G protein-coupled receptors. BJP. 2021; 178:
27-156. https://doi.org/10.1111/bph.15538
4. Xu W, Nathan PN, Balint L, et al. Orphan G-protein coupled receptor GPRC5B is
critical for lymphatic development. IJMS. 2022; 23(10): 5712. https://doi.org/10.3390/
ijms23105712
5. Watkins, LR, Orlandi, C. Orphan G protein coupled receptors in affective disorders.
Gen. 2020; 11(6): 694. https://doi.org/10.3390/genes11060694
6. Kozielewicz P, Alomar H, Yusof S, et al. N-glycosylation and expression in human
tissues of the orphan GPR61 receptor. FEBS Open Bio. 2017; 7(12): 1982-1993.
https://doi.org/10.1002/2211-5463.12339
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February 1, 2025
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